Polymer dynamics of Alp7A reveals how two critical concentrations govern assembly of dynamically unstable actin-like proteins

Mol Biol Cell. 2024 Nov 1;35(11):ar145. doi: 10.1091/mbc.E23-11-0440. Epub 2024 Sep 25.

Abstract

Dynamically unstable polymers capture and move cellular cargos in bacteria and eukaryotes, but regulation of their assembly remains poorly understood. Here we describe polymerization of Alp7A, a bacterial actin-like protein (ALP) that distributes copies of plasmid pLS20 among daughter cells in Bacillus subtilis. Purified ATP-Alp7A forms dynamically unstable polymers with a high critical concentration for net assembly (ccN = 10.3 µM), but a much lower critical concentration for filament elongation (ccE = 0.6 µM). Rapid nucleation and stabilization of Alp7A polymers by the accessory factor, Alp7R, decrease ccN into the physiological range. Stable populations of Alp7A filaments appear under two conditions: (i) when Alp7R slows catastrophe rates or (ii) when Alp7A concentrations are high enough to promote filament bundling. These results reveal how dynamic instability maintains high steady-state concentrations of monomeric Alp7A, and how accessory factors regulate Alp7A assembly by modulating ccN independently of ccE.

MeSH terms

  • Actin Cytoskeleton / metabolism
  • Actins* / metabolism
  • Adenosine Triphosphate / metabolism
  • Bacillus subtilis* / metabolism
  • Bacterial Proteins* / metabolism
  • Microfilament Proteins / metabolism
  • Plasmids / metabolism
  • Polymerization
  • Polymers / metabolism

Substances

  • Actins
  • Bacterial Proteins
  • Microfilament Proteins
  • Adenosine Triphosphate
  • Polymers