Prevalence and risk factors of suicidal ideation in oral cancer: a systematic review and meta-analysis

The objective was to estimate the pooled prevalence of suicidal ideation (SI) and related risk factors in oral cancer (OC). Studies that specified SI in OC patients were considered eligible. SI prevalence and associated risk factors were extracted from the included studies for qualitative analysis and meta-analysis. Five studies (two retrospective, two cross-sectional, and one prospective longitudinal) were included in this review. Out of a total 15,475 OC patients, SI was reported in 117. The pooled prevalence of SI was 6% (95% confidence interval 1-22%). The prevalence of SI varied widely across the included studies, from 0.26% to 18.7%. Four studies described SI assessment methods, which were DS-MV, PHQ-9, Beck Scale for Suicidal Ideation, and psychiatric interviews. Older age, depression, demoralization, previous cancer history, psychiatric history, alcohol dependence, anxiety, living alone, and poor quality of life were frequently mentioned as risk factors of SI. The prevalence of SI varied across studies and was probably affected by the method of assessment, treatment, and postoperative care. SI was consistently predicted with psychological distress. It is essential to raise awareness of demographic, clinical, and psychological associations with SI in order to assess risks and design interventions for this cohort.