ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway

Cancer Res Commun. 2024 Oct 1;4(10):2734-2755. doi: 10.1158/2767-9764.CRC-24-0268.

Abstract

ATF6 intervention reduces colorectal cancer cell and organoid viability by interrupting dysregulated Wnt signaling, identifying a novel facilitator and potential therapeutic target in colorectal cancer.

MeSH terms

  • Activating Transcription Factor 6* / genetics
  • Activating Transcription Factor 6* / metabolism
  • Animals
  • Cell Line, Tumor
  • Cell Proliferation
  • Colorectal Neoplasms* / genetics
  • Colorectal Neoplasms* / metabolism
  • Colorectal Neoplasms* / pathology
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Mice
  • Neoplastic Stem Cells* / metabolism
  • Neoplastic Stem Cells* / pathology
  • Wnt Signaling Pathway*

Substances

  • Activating Transcription Factor 6
  • ATF6 protein, human