Abstract
ATF6 intervention reduces colorectal cancer cell and organoid viability by interrupting dysregulated Wnt signaling, identifying a novel facilitator and potential therapeutic target in colorectal cancer.
©2024 The Authors; Published by the American Association for Cancer Research.
MeSH terms
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Activating Transcription Factor 6* / genetics
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Activating Transcription Factor 6* / metabolism
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Animals
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Cell Line, Tumor
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Cell Proliferation
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Colorectal Neoplasms* / genetics
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Colorectal Neoplasms* / metabolism
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Colorectal Neoplasms* / pathology
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Gene Expression Regulation, Neoplastic
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Humans
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Mice
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Neoplastic Stem Cells* / metabolism
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Neoplastic Stem Cells* / pathology
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Wnt Signaling Pathway*
Substances
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Activating Transcription Factor 6
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ATF6 protein, human