Non-Hotspot PIK3CA Variants Have Higher Variant Allele Frequency and are More Common in Syndromic Vascular Malformations

Affiliations

• ¹ Division of Pediatric Hematology and Oncology, Department of Pediatrics, Inselspital - University Hospital of Bern, University of Bern, Bern, Switzerland.
• ² Graduate School for Health Sciences, University of Bern, Bern, Switzerland.
• ³ Division of Angiology, Swiss Cardiovascular Center, Inselspital - University Hospital of Bern, University of Bern, Bern, Switzerland.
• ⁴ Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland.
• ⁵ SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
• ⁶ Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.
• ⁷ Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich (LMU), Munich, Germany.
• ⁸ DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
• ⁹ Department of Human Genetics, Inselspital - University Hospital of Bern, University of Bern, Bern, Switzerland.
• ¹⁰ Center for Vascular Anomalies, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
• ¹¹ VASCERN (European Network of Rare Vascular Diseases) Reference Center, VASCA Working Group, Brussels, Belgium.
• ¹² Vasc Alliance AG, Bern, Switzerland.
• ¹³ Bern Center for Vascular Medicine and Interventions, Bern, Switzerland.
• ¹⁴ Vascular Center, Bienna Hospital Center, Bienna, Switzerland.
• ¹⁵ Department of Human Genetics, Laboratory of Human Molecular Genetics, de Duve Institute, Catholic University of Louvain, Brussels, Belgium.
• ¹⁶ Department of Vascular Medicine, National Reference Centre for Rare Lymphatic and Vascular Diseases, UA11 INSERM - UM IDESP. Campus Santé, Montpellier Cedex 5, France.