Antioxidant intake and its relationship with generalized anxiety disorder among adults

Nutr Neurosci. 2024 Oct 8:1-11. doi: 10.1080/1028415X.2024.2408972. Online ahead of print.

Abstract

Antioxidant intake may contribute to the prevention of numerous diseases, particularly those related to stress-induced psychiatric and stress disorders. The current study aimed to assess the relationship between daily antioxidant intake (DAI) and Generalized Anxiety Disorder (GAD) in adults. It also sought to investigate the correlation between the type of diet in conjunction with DAI and the scores on GAD 7-Item Scale in adults. A cross-sectional design was used to examine if DAI was lower in individuals with GAD; followed by an interventional study of 40 adults with severe GAD, who were exposed to higher DAI for a period of 6 weeks. The results indicated that participants with severe GAD had significantly lower levels of DAI compared to healthy controls (p < 0.001). After 6 weeks of antioxidant supplementation, a significant decrease in GAD-7 scores of participants was observed (p < 0.001). The study found a significant negative relationship between DAI and GAD.

Keywords: Generalized anxiety disorder (GAD); adults; antioxidant supplementation; cross-sectional; daily antioxidant intake (DAI); generalized anxiety disorder 7-item scale (GAD-7); ‌interventional study.