Objective: To investigate the changes of directional connections of auditory and non-auditory in patients with noise-induced deafness (NID) by degree centrality (DC) and Granger causality analysis (GCA), and to explore the mode of brain function remodeling after NID. Methods: In October 2023, a total of 58 patients diagnosed with NID by the Occupational Diseases Department of Yantaishan Hospital of Yantai from 2014 to 2022 were collected as case group (NID group), and 42 healthy volunteers matched by gender, age and education level were selected as the control group (HC group). Resting state-functional magnetic resonance imaging (Rs-fMRI) was perfomed and PC analysis was performed. The brain regions with statistically significant differences in DC values between groups and the bilateral Heschl regions were extracted as regions of interest (ROI) for voxel-based whole brain GCA and correlation analysis. Results: Compared with HC group, the SOG.L DC value of NID group was lower, the connectivity values of SFGdor.L to SOG.L was increased, the connectivity value of PCL.L to SOG.L was decreased, the connectivity values of ORBmid.L, PCG.R and CUN. L/R to HES.L were increased, the connectivity value of SFGdor.L to HES.L was decreased, the connectivity value of HES.L to PCUN.L was decreased, the connectivity values of ORBsup.L and PCG.R to HES.R were increased, the connectivity value of HES.R to CUN.L was decreased (P voxel level<0.01, P cluster level<0.05). The connectivity value of PCL.L to SOG.L was negatively correlated with the weighted value of the better whisper frequency (P<0.05) . Conclusion: The NID patients have abnormal directional connectivity activity in multiple brain regions, such as auditory vision, executive control, somatosensory movement, and default mode network. It is suggested that hearing loss may cause complex neural remodeling between auditory and non-auditory centers.
目的： 采用度中心度（DC）及格兰杰因果分析（GCA）综合研究噪声聋（NID）患者听觉中枢及非听觉中枢定向连接的改变，探索噪声聋后的脑功能重塑模式。 方法： 于2023年10月，选择2014至2022年经烟台市烟台山医院职业病科确诊为NID的患者58例为病例组（NID组），选取性别、年龄、受教育程度相匹配的健康志愿者42例为对照组（HC组），行静息态脑功能磁共振成像（Rs-fMRI）并进行DC分析，根据结果选取组间DC值有统计学差异的脑区、双侧Heschl区为感兴趣区（ROI），进行基于体素的全脑GCA及相关分析。 结果： 与HC组比较，NID组左侧枕上回（SOG.L）DC值减低，左背侧额上回（SFGdor.L）到SOG.L的连接增高，左中央旁小叶（PCL.L）到SOG.L的连接减低；左眶部额中回（ORBmid.L）、右后扣带回（PCG.R）、双侧楔叶（CUN. L/R）到左侧颞横回（HES.L）连接增高，SFGdor.L到HES.L连接减低，HES.L到左楔前叶（PCUN.L）连接减低；左眶部额上回（ORBsup.L）、PCG.R到右侧颞横回（HES.R）连接增高，HES.R到CUN.L连接减低（P voxel level<0.01，P cluster level<0.05）。NID组PCL.L到SOG.L连接值与较好耳语频听阈加权值呈负相关（P<0.05）。 结论： NID患者听视觉、执行控制及体感运动、默认网络等多个脑区定向连接活动异常，提示听觉损失可造成听觉中枢及非听觉中枢之间发生复杂的脑功能网络神经重塑改变。.
Keywords: Causal connectivity; Cerebrum; Deafness; Degree centrality (DC); Granger causality analysis (GCA); Magnetic resonance imaging; Noise-induced deafness (NID).