Streptococcus suis, a bacterium commonly found in pigs, causes infections in humans through direct contact with infected animals or consumption of contaminated pork products. Recently, a localized outbreak of S. suis infection in humans resulted in three confirmed cases. All three patients had some form of contact with pigs in their medical history. One patient worked at a pig farm, whereas the other two consumed raw pork soup at the same restaurant. The patients were diagnosed with septicemia, subdural empyema, and infectious spondylitis. Streptococcus suis was isolated from their blood. This study was conducted to investigate the clinical features of three patients with S. suis infection and perform a molecular biological analysis of the strains obtained from them. Subsequent investigations highlighted the potential sources for this rare but serious infection and provided insight into preventive measures.