Choroidal biomarkers in age-related macular degeneration

Elham Sadeghi; Nicola Valsecchi; Elham Rahmanipour; Mahsa Ejlalidiz; Nasiq Hasan; Kiran Kumar Vupparaboina; Mohammed Nasar Ibrahim; Mohammed Abdul Rasheed; Jiwon Baek; Danilo Iannetta; Jay Chhablani

doi:10.1016/j.survophthal.2024.10.004

Choroidal biomarkers in age-related macular degeneration

Surv Ophthalmol. 2024 Oct 18:S0039-6257(24)00131-0. doi: 10.1016/j.survophthal.2024.10.004. Online ahead of print.

Authors

Affiliations

¹ University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. Electronic address: [email protected].
² University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA; Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. Electronic address: [email protected].
³ Immunology Research Center, Mashhad University of Medical Science, Mashhad, Iran. Electronic address: [email protected].
⁴ Research Institute of Ophthalmology and Vision Science, Shahid Beheshti University of Medical Science, Tehran, Iran. Electronic address: [email protected].
⁵ University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. Electronic address: [email protected].
⁶ University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. Electronic address: [email protected].
⁷ University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. Electronic address: [email protected].
⁸ School of Optometry and Vision Sciences, University of Waterloo, Ontario, Canada. Electronic address: [email protected].
⁹ Department of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea; Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: [email protected].
¹⁰ University of Rome La Sapienza Department of Organs of Sense, Rome, Italy. Electronic address: [email protected].
¹¹ University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. Electronic address: [email protected].

PMID: 39426529
DOI: 10.1016/j.survophthal.2024.10.004

Abstract

Age-related macular degeneration (AMD) is the leading cause of central visual impairment in the elderly. The exact pathophysiological mechanisms for AMD remain uncertain. Several studies suggest that choroidal abnormalities and alterations are critical in AMD progression. The transition from manual to automated segmentation and binarization techniques has resulted in accurate and precise measurements of different choroidal parameters. These qualitative and quantitative parameters, known as choroidal imaging biomarkers, have advanced from basic vertical subfoveal choroidal thickness to more intricate 3-dimensional choroidal reconstruction methods in the last decade. Therefore, a comprehensive evaluation of choroidal metrics may investigate valuable insights into AMD, potentially guiding the future development of customized therapeutic strategies and personalized patient care in AMD management. We describe the role of different choroidal biomarkers in evaluating patients with AMD and their contribution to management.

Keywords: Age-related macular degeneration; Choroidal biomarker; Choroidal contour analysis; Choroidal thickness; Choroidal vascularity; Choroidal vascularity index; Choroidal vessel layer thickness analysis; Choroidal volume.

Publication types

Review