Amine oxidase copper-containing 1 (AOC1) is a key member of copper amine oxidase family, which is responsible for deamination oxidation of histamine and putrescine. In recent years, AOC1 has been reported to be associated with various cancers, with its expression levels significantly elevated in certain cancer cells, suggesting its potential role in cancer progression. However, its function in lipid metabolism still remains unclear. Through genetic analysis, we have discovered a potential relationship between AOC1 and lipid metabolism. To further investigate, we generated Aoc1 -/- mice and characterized their metabolic phenotypes on both chow diet and high-fat diet (HFD) feeding conditions. On HFD feeding conditions, Aoc1 -/- mice exhibited significantly higher fat mass and impaired glucose sensitivity, and lipid accumulation in white adipose tissue and liver was also increased. This study uncovers the potential role of AOC1 in lipid metabolism and its implications in metabolic disorders such as obesity and type 2 diabetes, providing new targets and research directions for treating metabolic diseases.
含铜胺氧化酶1（AOC1）是含铜胺氧化酶家族中的关键成员，催化组胺和腐胺的脱氨氧化反应。近年来，AOC1被发现与多种癌症相关，它在某些癌细胞中的表达水平显著升高，提示可能在癌症进展中起到重要作用。然而，AOC1在脂代谢中的功能仍未被充分研究。通过遗传学分析，我们发现AOC1与脂代谢存在潜在关联。接着，我们构建了 Aoc1 −/−小鼠模型，并在标准饮食和高脂饮食条件下对其代谢表型进行了研究。实验结果显示，在高脂饮食条件下， Aoc1 −/−小鼠表现出体脂含量增加和葡萄糖耐受不良，白色脂肪组织和肝脏中的脂质积累显著增加。本研究揭示了AOC1在脂代谢中的潜在作用，以及它在代谢紊乱如肥胖和2型糖尿病中的潜在功能，为代谢性疾病的治疗提供了新的靶点和研究方向。.
Keywords: Amine oxidase copper-containing 1; Lipid metabolism; Obesity model.