Histopathological spectrum of primordial odontogenic tumor with co-existing dentigerous cyst: 1st reported case of the world with a proposed 'updated diagnostic criteria'

Diagn Pathol. 2024 Oct 29;19(1):143. doi: 10.1186/s13000-024-01560-8.

Abstract

Background: POT is a relatively newly described benign odontogenic tumor with very few cases registered to date. We present the 1st case of Primordial odontogenic tumor (POT) from Sub-Saharan Africa with unique clinicopathological features; also, this is the first case to report POT's existence as a Hybrid Odontogenic lesion (HOL), with a pertinent review of the literature.

Case presentation: This was a 17-year-old patient who presented with slow-growing, painless posterior mandibular swelling. The imaging revealed a well-defined, unilocular, expansile, lytic lesion with internal calcific foci surrounding an impacted #36, indicating a calcifying odontogenic cyst. The incisional biopsy revealed the presence of POT. The tumor was excised along with the involved tooth.

Conclusion: POT is predominantly a non-aggressive and mostly affects the pediatric population. Hence, clinicians must be updated on all the aspects of this tumor to diagnose it appropriately and avoid any undue over-or under-treatment.

Keywords: Definition proposal; Hybrid odontogenic lesion; New diagnostic criteria; Odontogenic tumor; Oral pathology; Primordial odontogenic tumor; Sub-Saharan Africa; WHO classification of odontogenic tumors.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Biopsy
  • Dentigerous Cyst* / diagnosis
  • Dentigerous Cyst* / pathology
  • Dentigerous Cyst* / surgery
  • Female
  • Humans
  • Male
  • Mandibular Neoplasms* / diagnosis
  • Mandibular Neoplasms* / pathology
  • Mandibular Neoplasms* / surgery
  • Odontogenic Tumors* / diagnosis
  • Odontogenic Tumors* / pathology
  • Odontogenic Tumors* / surgery