TAM-ing the beast with IL-34 blockade

Sci Immunol. 2024 Nov;9(101):eadu0981. doi: 10.1126/sciimmunol.adu0981. Epub 2024 Nov 1.

Authors

Aron Gyorgypal¹, Robert M Anthony¹

Affiliation

¹ Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

PMID: 39485858
DOI: 10.1126/sciimmunol.adu0981

Abstract

TP53 mutation triggers IL-34 secretion by cancer stem cells, reprogramming macrophages to suppress T cells and promote tumor immune escape.

MeSH terms

Animals
Humans
Interleukins* / antagonists & inhibitors
Interleukins* / genetics
Interleukins* / immunology
Macrophages / immunology
Mice
Mutation
Neoplasms / drug therapy
Neoplasms / immunology
Neoplastic Stem Cells / immunology
Tumor Escape / immunology
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / immunology

Substances

Interleukins
IL34 protein, human
Tumor Suppressor Protein p53