Cu(I)-Catalyzed Silylation and Germylation of Azauracils

The current study demonstrates a Cu(I) catalyzed direct C(sp2)-H silylation and germylation of azauracil using triphenylsilane and triphenylgermane. A broad scope, excellent functional group tolerance, and suitability for large-scale reactions are exhibited in this protocol. Moreover, this method can be readily applied to structurally complex bioactive molecules. Experimental results suggest a radical mechanistic pathway for the reaction.