Role of Nasopharyngeal Airway in Management of Craniofacial Syndrome-Associated Upper Airway Obstruction in Children

Samara Thambar; Matthew D Wong; Sandra Schilling; Nitin Kapur

doi:10.1111/ocr.12872

Role of Nasopharyngeal Airway in Management of Craniofacial Syndrome-Associated Upper Airway Obstruction in Children

Orthod Craniofac Res. 2024 Nov 6. doi: 10.1111/ocr.12872. Online ahead of print.

Authors

Samara Thambar¹, Matthew D Wong^{1

2}, Sandra Schilling¹, Nitin Kapur^{1

2}

Affiliations

¹ Department of Paediatric Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Australia.
² Children's Health Queensland Clinical Unit, Faculty of Medicine, The University of Queensland, South Brisbane, Australia.

PMID: 39503249
DOI: 10.1111/ocr.12872

Abstract

Introduction: Upper airway obstruction (UAO) management in children, particularly those with associated anatomical mid-face structural differences, poses a significant challenge. This study describes using a nasopharyngeal airway (NPA) in managing infants with severe upper airway obstruction.

Methods: Infants discharged home from Queensland Children's Hospital with an NPA in situ for the management of upper airway obstruction were retrospectively evaluated for clinical and demographic parameters, underlying diagnoses and respiratory support, including NPA insertion details and comorbidities.

Results: Sixty-seven children (24 male) were included with a median age at NPA insertion of 24 (IQR 7-59) days and a median duration of NPA use of 229.1 (IQR 151.50-297.75) days. Fifty-two (77.6%) had Pierre Robin sequence. Other diagnoses included CHARGE syndrome, Treacher Collins syndrome, Stickler syndrome, Crouzon syndrome, Bohring-Opitz syndrome, isolated cleft palate, Beckwith-Wiedemann syndrome, Chromosome 3 deletion and VACTERL association. Four infants required tracheostomy, and no complications related to NPA use were reported. Those with oximetry and polysomnography data showed improving indices following NPA insertion [pre NPA median (IQR) SpO₂: 95.9% (94.73-97.73), AHI: 51.40 (44.50-69.45), OAHI 65.9 (56.45-73.35) and TcCO₂ (mmHg) 65.70 (61.95-67.30) vs. post-NPA median (IQR) SpO₂: 97.1% (96.19-97.9), AHI: 12.20 (11.25-24.35), OAHI 10.20 (6.12-5.62) and TcCO₂ (mmHg) 52.40 (47.90-58.40)].

Conclusion: Our findings highlight the effectiveness and safety of NPA as a noninvasive management option for severe upper airway obstruction in children, particularly in those with anatomical midface structural differences. Further research and larger studies are warranted to confirm these findings and optimise management strategies for these patients.