Expert consensus on workflow of PET/CT with long axial field-of-view

Guobing Liu; Yushen Gu; Martina Sollini; Alexandra Lazar; Florent L Besson; Sijin Li; Zhifang Wu; Lorenzo Nardo; Akram Al-Ibraheem; Jiefu Zheng; Harshad R Kulkarni; Axel Rominger; Wei Fan; Xiaohua Zhu; Xinming Zhao; Hubing Wu; Jianjun Liu; Biao Li; Zhaoping Cheng; Ruimin Wang; Baixuan Xu; Denis Agostini; Han Tang; Lijie Tan; Zhi Yang; Li Huo; Jianying Gu; Hongcheng Shi

doi:10.1007/s00259-024-06968-4

Expert consensus on workflow of PET/CT with long axial field-of-view

Eur J Nucl Med Mol Imaging. 2024 Nov 9. doi: 10.1007/s00259-024-06968-4. Online ahead of print.

Authors

Guobing Liu^#^{1

2

3}, Yushen Gu^#^{4

1

2

3}, Martina Sollini^#^{5

6}, Alexandra Lazar⁵, Florent L Besson^{7

8}, Sijin Li⁹, Zhifang Wu⁹, Lorenzo Nardo¹⁰, Akram Al-Ibraheem^{11

12}, Jiefu Zheng¹³, Harshad R Kulkarni^{14

15}, Axel Rominger¹⁶, Wei Fan¹⁷, Xiaohua Zhu¹⁸, Xinming Zhao¹⁹, Hubing Wu²⁰, Jianjun Liu²¹, Biao Li²², Zhaoping Cheng²³, Ruimin Wang²⁴, Baixuan Xu²⁴, Denis Agostini²⁵, Han Tang^{3

26}, Lijie Tan^{3

26}, Zhi Yang²⁷, Li Huo^{28

29}, Jianying Gu^{30

31

32

33}, Hongcheng Shi^{34

35

36

37

38

39}

Affiliations

¹ Shanghai Institute of Medical Imaging, Shanghai, 200032, P.R. China.
² Institute of Nuclear Medicine, Fudan University, Shanghai, 200032, P.R. China.
³ Cancer Prevention and Treatment Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, P.R. China.
⁴ Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.
⁵ Vita-Salute San Raffaele University, Via Olgettina 58, 20132, Milan, Italy.
⁶ Department of Nuclear Medicine, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy.
⁷ Department of Nuclear Medicine-Molecular Imaging, Hôpitaux Universitaires Paris-Saclay, AP-HP, DMU Smart Imaging, CHU Bicêtre, Paris, France and Université Paris-Saclay, Commissariat À L'énergie Atomique Et Aux Énergies Alternatives (CEA), Centre National de La Recherche Scientifique (CNRS), InsermBioMaps, Orsay, France.
⁸ Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France.
⁹ Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Collaborative Innovation Center for Molecular Imaging Precision Medicine, Taiyuan, 030001, P.R. China.
¹⁰ Department of Radiology, University of California Davis, Sacramento, CA, 95819, USA.
¹¹ Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman, 11941, Jordan.
¹² Department of Radiology and Nuclear Medicine, School of Medicine, University of Jordan, Amman, 11942, Jordan.
¹³ Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Medical Imaging, University of Virginia School of Medicine, 1215 Lee Street, Charlottesville, VA, 22908-0170, USA.
¹⁴ BAMF Health, Grand Rapids, MI, 49503, USA.
¹⁵ Department of Radiology, Michigan State University College of Human Medicine, East Lansing, MI, 48824, USA.
¹⁶ Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, CH-3010, Bern, Switzerland.
¹⁷ Department of Nuclear Medicine, Sun Yat-Sen University Cancer Center, No. 651 Dongfengdong Road, Guangzhou, 510060, P.R. China.
¹⁸ Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, P.R. China.
¹⁹ Department of Nuclear Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei Province, P.R. China.
²⁰ Nanfang PET Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, P.R. China.
²¹ Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 PuJian Road, Shanghai, 200127, P.R. China.
²² Department of Nuclear Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197 Ruijin Er Road, Shanghai, 200025, P.R. China.
²³ Department of Nuclear Medicine, The First Affiliated Hospital of Shandong First Medical University, No. 16766 Jingshi Road, Jinan, 250014, Shandong, P.R. China.
²⁴ Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, P.R. China.
²⁵ Department of Nuclear Medicine, University Hospital of Caen and Normandie Université, EA, 4650, Caen, France.
²⁶ Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P.R. China.
²⁷ Key Laboratory of Carcinogenesis and Translational Research, (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, P.R. China.
²⁸ Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, 100730, P.R. China.
²⁹ Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, P.R. China.
³⁰ Cancer Prevention and Treatment Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, P.R. China. [email protected].
³¹ Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P.R. China. [email protected].
³² Department of Plastic Surgery, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, P.R. China. [email protected].
³³ Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province, Xiamen, 361015, P.R. China. [email protected].
³⁴ Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China. [email protected].
³⁵ Shanghai Institute of Medical Imaging, Shanghai, 200032, P.R. China. [email protected].
³⁶ Institute of Nuclear Medicine, Fudan University, Shanghai, 200032, P.R. China. [email protected].
³⁷ Cancer Prevention and Treatment Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, P.R. China. [email protected].
³⁸ Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province, Xiamen, 361015, P.R. China. [email protected].
³⁹ Department of Nuclear Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, P.R. China. [email protected].

^# Contributed equally.

PMID: 39520515
DOI: 10.1007/s00259-024-06968-4

Abstract

Purpose: Positron emission tomography/computed tomography (PET/CT) imaging has been widely used in clinical practice. Long axial field-of-view (LAFOV) systems have enhanced clinical practice by leveraging their technological advantages and have emerged as the new state-of-the-art PET imaging modalities. A consensus was conducted to explore expert views in this emerging field to comprehensively elucidate the proposed workflow in LAFOV PET/CT examinations and highlight the potential challenges inherent in the workflow.

Methods: A multidisciplinary task group formed by 28 experts from six countries over the world discussed and approved the consensus based on the published guidelines, peer-reviewed articles of LAFOV PET/CT, and the collective experience from clinical practice. This consensus focuses on the workflow that allows for a broader range of imaging protocols of LAFOV PET/CT, catering to diverse patient needs and in line with precision medicine principles.

Results: This consensus describes the workflows and imaging protocols of LAFOV PET/CT for various imaging scenarios including routine static imaging, dynamic imaging, low-activity imaging, fast imaging, prolonged imaging, delayed imaging, and dual-tracer imaging. In addition, imaging reconstruction and reviewing specific to LAFOV PET/CT imaging, as well as the main challenges facing installation and application of LAFOV PET/CT scanner were also summarized.

Conclusion: This consensus summarized the various imaging workflow, imaging protocol, and challenges of LAFOV PET/CT imaging, aiming to enhance the clinical and research applications of these scanners.

Keywords: Expert consensus; Imaging protocols; Imaging workflow; Long axial field-of-view; Positron emission tomography/computed tomography (PET/CT); Total-body imaging.

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Abstract

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