A new benzodioxole derivative from the marine-derived Streptomyces sp. SYPHU 0002

Nat Prod Res. 2024 Nov 9:1-7. doi: 10.1080/14786419.2024.2425058. Online ahead of print.

Abstract

a new benzodioxole derivative 1,3-benzodioxole-2-one-4-N-methylcarboxylamide (1), two new natural products N-(aminocarbonyl)-2,3-dimethoxy-benzamide (2) and 2,3-dimethoxy-N-methylbenzamide (3), along with eight known compounds (4-11), were isolated from the marine-derived Streptomyces sp. SYPHU 0002. The structures of compounds 1-11 were determined through comprehensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR. Compound 9 showed weak antibacterial activity against Bacillus pumilus with the MIC value of 64 μg mL-1.

Keywords: Antibacterial activity; Natural product; Streptomyces sp; marine-derived.