Current and emerging therapeutic strategies for perianal fistula in Crohn's disease patients

Kailei Ding; Jiayuan Kong; Ling Li; Florin M Selaru; Alyssa Parian; Hai-Quan Mao

doi:10.1016/bs.apha.2024.10.013

Current and emerging therapeutic strategies for perianal fistula in Crohn's disease patients

Adv Pharmacol. 2024:101:159-182. doi: 10.1016/bs.apha.2024.10.013. Epub 2024 Oct 24.

Authors

Kailei Ding¹, Jiayuan Kong¹, Ling Li², Florin M Selaru³, Alyssa Parian⁴, Hai-Quan Mao⁵

Affiliations

¹ Institute for NanoBioTechnology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Materials Science and Engineering, Whiting School of Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
² Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
³ Institute for NanoBioTechnology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
⁴ Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: [email protected].
⁵ Institute for NanoBioTechnology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Materials Science and Engineering, Whiting School of Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: [email protected].

PMID: 39521599
DOI: 10.1016/bs.apha.2024.10.013

Abstract

The long-term remission rates achieved with current treatment options for Crohn's disease with perianal fistula (CD-PAF)-including antibiotics, biologics, immunomodulators, and Janus kinase inhibitors, often combined with advanced surgical interventions-remain unsatisfactory. This chapter explores several innovative biomaterials-based solutions, such as plugs, adhesives, fillers, and stem cell-based therapies. The key approaches and treatment outcomes of these advanced therapies are examined, focusing on their ability to modulate the immune response, promote tissue healing, and improve patient outcomes. Additionally, the chapter discusses future directions, including the optimization of biomaterial designs, enhancement of delivery and retention of regenerative therapies, and a deeper understanding of the underlying mechanisms of healing.

Keywords: Biomaterials; Crohn’s disease; Perianal fistula; Stem cell-based therapies; Tissue healing.

Publication types

Review

MeSH terms

Animals
Biocompatible Materials
Crohn Disease* / drug therapy
Crohn Disease* / therapy
Humans
Rectal Fistula* / etiology
Rectal Fistula* / therapy

Substances

Biocompatible Materials