Ultrastructural effects of Staphylococcus aureus toxicity on albino mice kidney

Staphylococcus aureus (S. aureus) is a prominent infectious etiological agent in humans, dairy animals, and camels. Camel milk has all the nutrients which are nutritious and advantageous to the growth of S. aureus that dominates most bacterial species. So, the present work was designed to investigate the effect of certain toxin gene of S. aureus bacteria isolated from raw camel milk on the fine structure of mice kidneys. Two toxin genes of S. aureus were identified and described through PCR using 23s rRNA primer for 23s rRNA gene. In addition, the effect of the isolated S. aureus bacteria, especially those carrying the gene "tst" was studied on the ultrastructure of mice kidney. Twenty male albino mice were allocated into 2 groups, control group and infected group (orally administered with a single dosage of S. aureus aqueous solutions from camel milk at a concentration of 5 × 10⁸ colony forming unit/0.1 mL for three days). Infection of mice with S. aureus resulted in vacuolation, necrosis, and degeneration of tubular epithelial cells, intertubular congestion and inflammation, as well as dilatation and congestion of glomeruli. Therefore, this current study most likely indicates that camel milk infected with S. aureus has a significant and clear impact in inducing symptoms of kidney failure in communities that use these dairy products without health supervision, especially nomadic and pastoral communities.