Cost-effective synthesis and application of Cu²⁺-doped melamine formaldehyde resin for enhanced tetracycline enrichment in environmental water

Lin Gu; Junyu Zhang; Shuhai Ding; Longlong Wang; Wei Xia; Peng Wang; Wenlei Zhai; Cong Kong; Xiaosheng Shen; Chengqi Fan; Guangxin Yang

doi:10.1016/j.chroma.2024.465499

Cost-effective synthesis and application of Cu²⁺-doped melamine formaldehyde resin for enhanced tetracycline enrichment in environmental water

J Chromatogr A. 2024 Nov 2:1738:465499. doi: 10.1016/j.chroma.2024.465499. Online ahead of print.

Authors

Lin Gu¹, Junyu Zhang², Shuhai Ding², Longlong Wang³, Wei Xia², Peng Wang³, Wenlei Zhai⁴, Cong Kong⁵, Xiaosheng Shen³, Chengqi Fan³, Guangxin Yang⁶

Affiliations

¹ School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, 200093, PR China.
² School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, 200093, PR China; East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, PR China.
³ East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, PR China.
⁴ Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Middle Road of Shuguanghuayuan, Haidian District, Beijing 100097, PR China.
⁵ School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, 200093, PR China; East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, PR China. Electronic address: [email protected].
⁶ Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, (Academy of Forensic Science), PR China. Electronic address: [email protected].

PMID: 39531995
DOI: 10.1016/j.chroma.2024.465499

Abstract

Tetracycline antibiotics (TCs) are typically present at low residue levels in environmental water, necessitating enrichment prior to analysis. In this study, a Cu²⁺-doped melamine formaldehyde resin (Cu-MFR) was synthesized to enhance the adsorption efficiency for TCs, leveraging the formation of stable Cu²⁺-TC complexes on the sorbent surface. Then it was used as an adsorbent in solid-phase extraction (SPE) for the enrichment of four TCs from water samples. The optimized parameters for Cu-MFR in the analysis of TCs in environmental water enabled linear detection ranges from 0.20 to 50 ng/mL, with relative recoveries ranging from 79.5 % to 97.6 % and relative standard deviations ≤ 10.0 %, using high-performance liquid chromatography-tandem high-resolution mass spectrometry (HPLC-HRMS). The limits of detection for the four TCs were determined to be between 0.11 and 0.16 ng/mL, indicating its potential for practical application in real sample analysis.

Keywords: Adsorbent; Mass spectrometry; Melamine resin; Tetracycline; Water environment.