Zn2+ and ClO- may be associated with a variety of pathologies, and their simultaneous measurement is crucial for disease diagnosis and environmental protection. In this work, we synthesized an independent AIE probe, HNTE, through a one step reaction. The probe HNTE displayed a distinctive fluorescence color change from deep yellow to blue for ClO- and to green for Zn2+. More importantly, the probe HNTE could simultaneously detect endogenous and exogenous ClO- and Zn2+ in living cells colorimetrically via the blue and green channels.