mRNA vaccines: A promising platform for safer, more effective next-generation Orthopoxvirus immunization

Xiaonan Han; Qingrui Huang; Jinghua Yan

doi:10.1016/j.chom.2024.10.014

mRNA vaccines: A promising platform for safer, more effective next-generation Orthopoxvirus immunization

Cell Host Microbe. 2024 Nov 13;32(11):1884-1886. doi: 10.1016/j.chom.2024.10.014.

Authors

Xiaonan Han¹, Qingrui Huang², Jinghua Yan³

Affiliations

¹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
² Changping Laboratory, Beijing, China.
³ Changping Laboratory, Beijing, China. Electronic address: [email protected].

PMID: 39541944
DOI: 10.1016/j.chom.2024.10.014

Abstract

In recent work, Mucker et al.¹ demonstrated that mRNA-1769 outperforms modified vaccinia Ankara (MVA), which has been deployed against recent mpox virus (MPXV) outbreaks, in reducing clinical symptoms and controlling viral replication, highlighting its potential as a scalable, safe, and effective next-generation platform for orthopoxvirus vaccination.

MeSH terms

Animals
Humans
Immunization
Mice
Orthopoxvirus* / genetics
Orthopoxvirus* / immunology
Poxviridae Infections* / prevention & control
Vaccination
Vaccines, Synthetic / genetics
Vaccines, Synthetic / immunology
Vaccinia virus / genetics
Vaccinia virus / immunology
Viral Vaccines / genetics
Viral Vaccines / immunology
Virus Replication
mRNA Vaccines*

Substances

mRNA Vaccines
Viral Vaccines
Vaccines, Synthetic