Sensorable zwitterionic antibacterial hydrogel for wound electrostimulation therapy

Jinghua Li; Meijun Chen; Shaowen Cheng; Shegan Gao; Jingming Zhai; Dongmei Yu; Jianping Wang; Jianbo Zhang; Kaiyong Cai

doi:10.1016/j.biomaterials.2024.122958

Sensorable zwitterionic antibacterial hydrogel for wound electrostimulation therapy

Biomaterials. 2024 Nov 9:315:122958. doi: 10.1016/j.biomaterials.2024.122958. Online ahead of print.

Authors

Jinghua Li¹, Meijun Chen², Shaowen Cheng³, Shegan Gao⁴, Jingming Zhai², Dongmei Yu⁵, Jianping Wang⁵, Jianbo Zhang⁶, Kaiyong Cai⁷

Affiliations

¹ The 1st Affiliated Hospital, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, 471000, China; Key Laboratory of Emergency and Trauma of Ministry of Education, Department of Wound Repair, The First Affiliated Hospital, College of Emergency and Trauma, Hainan Medical University, Haikou, 570100, China; Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining, 810008, China. Electronic address: [email protected].
² The 1st Affiliated Hospital, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, 471000, China.
³ Key Laboratory of Emergency and Trauma of Ministry of Education, Department of Wound Repair, The First Affiliated Hospital, College of Emergency and Trauma, Hainan Medical University, Haikou, 570100, China.
⁴ The 1st Affiliated Hospital, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, 471000, China. Electronic address: [email protected].
⁵ Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining, 810008, China.
⁶ Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, China.
⁷ Key Laboratory of Biorheological Science and Technology, Chongqing University, Chongqing, 400044, China. Electronic address: [email protected].

PMID: 39547138
DOI: 10.1016/j.biomaterials.2024.122958

Abstract

Wound healing process has always been a focal point of concern, with a plethora of hydrogel dressings available; however, their therapeutic efficacy remains a hindrance to wound closure. This article reports on a dual-network conductive system, PEDOT:PSS-co-PSBMA/XLG (PPSX) hydrogel dressing, Constructed using poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT: PSS) in combination with zwitterionic N, N-dimethyl-N-(2-methacryloyloxyethyl)-N- (3-sulfopropyl) ammonium betaine (SBMA) and nanoclay-synthesized lithium magnesium silicate (XLG). The hydrogel powder produced from it can absorb interfacial water within 30 s via physical interactions to spontaneously form hydrogels of arbitrary shapes. With a conductivity of 1.8 s/m, it can be utilized for developing flexible sensing bioelectronic devices to monitor human activities (facial expressions, blinking, swallowing, speaking, joint movements), as well as constructing electrodes for monitoring muscle movements and motorial intensity. More importantly, PPSX hydrogel effectively inhibits bacterial growth and promotes cell proliferation, thus facilitating wound healing and presenting extensive application prospects in the medical field.

Keywords: Electrotherapy; Hydrogel conductor; Sensing property; Wound healing.