Validation of direct recording of electrically evoked cortical auditory evoked potentials through a cochlear implant system

Sci Rep. 2024 Nov 17;14(1):28366. doi: 10.1038/s41598-024-79528-3.

Abstract

Cochlear implants (CI) are one of the most successful treatments available to enable individuals with severe to profound hearing loss to regain access to the world of sound. This is accomplished through the electrical stimulation of the auditory nerve using electrodes implanted inside the cochlea. The use of subjective user feedback makes the process of fitting these devices much more challenging in cases where users are not able to actively or accurately report their experience (e.g. pediatrics), making an objective measurement that reflects the accuracy or effectiveness of a program quite attractive. We recorded one objective measure, the electrically-stimulated cortical auditory evoked potential (eCAEP), non-invasively using the CI in response to a simulated speech sound in seven adult participants and compared it to their eCAEP recorded using a scalp EEG set-up. The eCAEPs recorded with CI electrodes were comparable to scalp recorded eCAEPs (grand mean cross-correlation of r = 0.83, individual mean cross-correlations ranged from 0.13 to 0.70). Evoked potential peaks P1, N1 and P2 showed no significant latency difference based on if the eCAEP was recorded on the scalp or using the CI. The eCAEP waveforms recorded via the CI appear to converge in a distinct P1-N1-P2 waveform by as early as 130 sweeps. In conclusion, in this study we show the feasibility of recording the eCAEP directly through the CI system, which could potentially be used to guide CI fitting and track auditory cortex development in response to CI use.

Keywords: Auditory cortex; Cochear implant; Cortical auditory evoked potential; EEG; Hearing loss; Maturation.

Publication types

  • Validation Study

MeSH terms

  • Adult
  • Auditory Cortex / physiology
  • Cochlear Implantation / methods
  • Cochlear Implants*
  • Electric Stimulation / methods
  • Electroencephalography / methods
  • Evoked Potentials, Auditory* / physiology
  • Female
  • Hearing Loss / physiopathology
  • Hearing Loss / surgery
  • Hearing Loss / therapy
  • Humans
  • Male
  • Middle Aged
  • Young Adult