Objective: To investigate the comorbidity status of hypertension, diabetes, and dyslipidemia (the"three diseases") among residents aged≥40 in Liaoning Province, and to explore the correlation between the comorbidity and cardiovascular disease mortality. Methods: This investigation was a prospective cohort study. From February 2017 to March 2019, a multi-stage stratified cluster random sampling method was used to carry out a baseline survey of 18 758 permanent residents aged≥40 years in Liaoning Province. Demographic information and history of hypertension, diabetes, and dyslipidemia were collected and followed up every year. Death was mainly identified by linkage to the Population Death Information Registration Management System. Cox proportional hazard regression model was used to analyze the association between the comorbidity of the "three diseases" and cardiovascular disease mortality risk. Results: A total of 18 758 residents aged≥40 in Liaoning Province were included, with an age of (60.3±9.9) years and 7 325 males (39.1%). The comorbidity rate of hypertension, diabetes, and dyslipidemia was 6.7% (1 256/18 758), and the standardized prevalence rate was 5.4%. The comorbidity rate increased with age (P<0.001), which was higher in women than in men, and more significant in urban areas than in rural areas (all P<0.001). The comorbidity of "three diseases" accounted for 39.3% (1 256/3 198), 18.7% (1 256/6 710), and 11.8% (1 256/10 653) in patients with diabetes, dyslipidemia, and hypertension, respectively. With a follow-up of (4.3±0.6) years, 463 people died of cardiovascular disease. The mortality rate of cardiovascular disease in the comorbidity of hypertension, diabetes, and dyslipidemia was 8.74/1 000 person-years. After adjusting potential confounders, Cox proportional hazard regression model analysis showed that compared with normal individuals, the hazard ratio of cardiovascular disease mortality in patients with the "three diseases" was 2.55 (95%CI: 1.63-3.99). Conclusion: The prevalence of comorbidity of hypertension, diabetes, and dyslipidemia among residents aged≥40 in Liaoning Province was relatively high, and the risk of cardiovascular disease mortality in patients with the "three diseases" was increased.
目的： 了解辽宁省≥40岁居民高血压、糖尿病和血脂异常共病（三高）的现况，探讨三高与心血管病死亡风险的关联。 方法： 本次调查为前瞻性队列研究，于2017年2月—2019年3月，采用多阶段分层整群随机抽样的方法对辽宁省≥40岁常住居民开展基线调查，收集人口学信息及高血压、糖尿病和血脂异常病史等，并每年进行随访，死亡信息主要通过人口死亡信息登记管理系统获取。采用Cox比例风险回归模型分析三高与心血管病死亡风险之间的关联。 结果： 共纳入辽宁省≥40岁城乡居民18 758人，年龄（60.3±9.9）岁，男性7 325人（39.1%）。三高患病率为6.7%（1 256/18 758），标化患病率为5.4%，随着年龄的增长呈上升趋势，女性高于男性，城市高于农村（P均<0.001）。三高者在糖尿病患者、血脂异常患者和高血压患者中分别占39.3%（1 256/3 198）、18.7%（1 256/6 710）和11.8%（1 256/10 653）。随访（4.3±0.6）年，共463例心血管病死亡，三高患者心血管病死亡率为8.74/1 000人年。经多因素调整后，Cox比例风险回归模型分析结果显示，与正常者相比，三高患者心血管病死亡的HR=2.55（95%CI：1.63~3.99）。 结论： 辽宁省≥40岁居民三高患病率较高，且三高患者心血管病死亡风险增加。.