Multisystem inflammatory syndrome in adults hospitalizations in the United States; evaluating patient characteristics, COVID-19 associations, and mortality

Introduction: Multisystem inflammatory syndrome in adults (MIS-A) is thought to be closely linked with COVID-19 infection. This study aims to elucidate the demographics and clinical characteristics of MIS-A, aiding in timely diagnosis and management.

Methods: Utilizing the National Inpatient Sample (NIS) database (2021), patients were stratified into MIS-A and non-MIS-A groups. Baseline characteristics and comorbidities, the association with COVID-19, post-COVID-19 syndrome, and personal history of COVID-19, as well as impact on mortality were studied.

Results: We identified 2,730 adults with MIS-A. MIS-A was linked with active COVID-19 infection (aOR = 27.436, p < 0.001), post-COVID-19 syndrome (aOR = 32.766, p < 0.001), personal history of COVID-19 (aOR = 2.963, p < 0.001), and an increased mortality (aOR = 3.743, p < 0.001).

Conclusions: Using data adjusted for confounding variables, MIS-A was found to be associated with active and past COVID-19, and a greater mortality rate when compared to non-MIS-A patients.