Abstract
The time of re-implantation of removed CIED for local infection or endocarditis has been debated because no randomized studies are available. Many authors prefer to delay reimplantation to the time of blood culture negative or clinical stability. In this case report we describe the case of E. faecalis CIED endocarditis treated with the combination ampicillin plus ceftobiprole and one-stage removal and re-implantation with early follow-up without relapse of infection. In case of E. faecalis infection, we hypothesize that ampicillin plus ceftobiprole combination might have bactericidal and anti-biofilm activity, therefore allowing one state re-implantation without relapse.
Keywords:
CIED; E. faecalis; Transvenous removal; ampicillin; antibiofilm therapy; ceftobiprole.
MeSH terms
-
Aged
-
Ampicillin* / administration & dosage
-
Ampicillin* / therapeutic use
-
Anti-Bacterial Agents* / administration & dosage
-
Anti-Bacterial Agents* / therapeutic use
-
Cephalosporins* / administration & dosage
-
Cephalosporins* / therapeutic use
-
Defibrillators, Implantable
-
Device Removal
-
Drug Therapy, Combination
-
Endocarditis, Bacterial* / drug therapy
-
Endocarditis, Bacterial* / microbiology
-
Enterococcus faecalis* / drug effects
-
Enterococcus faecalis* / isolation & purification
-
Gram-Positive Bacterial Infections* / drug therapy
-
Gram-Positive Bacterial Infections* / microbiology
-
Humans
-
Male
-
Pacemaker, Artificial / adverse effects
-
Pacemaker, Artificial / microbiology
-
Prosthesis-Related Infections / drug therapy
-
Prosthesis-Related Infections / microbiology
Substances
-
Ampicillin
-
Anti-Bacterial Agents
-
Cephalosporins
-
ceftobiprole