Characterization of dog hepatic drug-metabolizing enzymes and resultant effects on benzo[a]pyrene metabolite pattern and mutagenicity

Drug Metab Dispos. 1980 May-Jun;8(3):121-6.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • 7-Alkoxycoumarin O-Dealkylase
  • Animals
  • Benzo(a)pyrene
  • Benzopyrenes / metabolism*
  • Benzopyrenes / pharmacology
  • Chromatography, High Pressure Liquid
  • Cytochrome P-450 Enzyme System / metabolism
  • Dogs / metabolism*
  • Epoxide Hydrolases / metabolism
  • Glutathione Transferase / metabolism
  • Male
  • Microsomes, Liver / enzymology*
  • Microsomes, Liver / metabolism
  • Mutation
  • Oxygenases / antagonists & inhibitors
  • Oxygenases / metabolism
  • Rats
  • Salmonella typhimurium / drug effects
  • Species Specificity

Substances

  • Benzopyrenes
  • Benzo(a)pyrene
  • Cytochrome P-450 Enzyme System
  • Oxygenases
  • 7-Alkoxycoumarin O-Dealkylase
  • Glutathione Transferase
  • Epoxide Hydrolases