Folate analogues altered in the C9--N10 bridge region. 14. 11-Oxahomofolic acid, a potential antitumor agent

J Med Chem. 1980 Jan;23(1):59-65. doi: 10.1021/jm00175a011.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Drug Resistance, Microbial
  • Folic Acid / analogs & derivatives*
  • Folic Acid Antagonists
  • Lacticaseibacillus casei / drug effects
  • Lacticaseibacillus casei / enzymology
  • Methotrexate / pharmacology
  • Streptococcus / drug effects
  • Structure-Activity Relationship
  • Tetrahydrofolate Dehydrogenase / metabolism
  • Thymidylate Synthase / antagonists & inhibitors
  • Thymidylate Synthase / metabolism

Substances

  • Antineoplastic Agents
  • Folic Acid Antagonists
  • homofolic acid
  • 11-oxahomofolic acid
  • Folic Acid
  • Tetrahydrofolate Dehydrogenase
  • Thymidylate Synthase
  • Methotrexate