After a short introduction regarding the concept of "secreting" lymphoma and the most recent theories about the dynamics of normal and pathologic lymphocytes, resulting from the actual immunologic advancements and designed in order do give an explanation of some of the problems concerned with these diseases, such as "classification", "transmutation" of one type of lymphoma into another and the lymphoma/leukemia question, the authors go on describing few personal cases taken as examples. Finally, upon having pointed out that following now a day's whole population screening there is an always more increasing number of asymptomatic "secreting" lymphomas, casually diagnosed, the authors call the general practitioners' attention on the most common clinical and laboratory features that should lead to suspect a lymphoma of this type.