Comparison of the hydroxylation of benzo(a)pyrene with the metabolism of vinyl chloride, N-nitrosomorpholine, and N-nitroso-N'-methylpiperazine to mutagens by human and rat liver microsomal fractions

Cancer Res. 1980 Jan;40(1):119-26.
No abstract available

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Aryl Hydrocarbon Hydroxylases / metabolism
  • Benzopyrenes / metabolism*
  • Biotransformation
  • Female
  • Humans
  • Hydroxylation
  • In Vitro Techniques
  • Male
  • Methylcholanthrene / pharmacology
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism*
  • Morpholines / metabolism*
  • Mutagens / metabolism*
  • Nitrosamines / metabolism*
  • Piperazines / metabolism*
  • Rats
  • Vinyl Chloride / metabolism*
  • Vinyl Compounds / metabolism*

Substances

  • Benzopyrenes
  • Morpholines
  • Mutagens
  • Nitrosamines
  • Piperazines
  • Vinyl Compounds
  • N-nitrosomorpholine
  • N-nitroso-N'-methylpiperazine
  • Methylcholanthrene
  • Aryl Hydrocarbon Hydroxylases
  • Vinyl Chloride