Abstract
Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theiler's virus-induced disease but is not required for myelin destruction.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / pharmacology*
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Antibodies, Viral / biosynthesis
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Antigens, Viral / analysis
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Antigens, Viral / biosynthesis
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Disease Susceptibility
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Enzyme-Linked Immunosorbent Assay
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Female
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Immunity, Innate
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Immunoglobulin G / biosynthesis
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Immunoglobulin M / biosynthesis
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Inflammation
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Interferon-gamma / immunology
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Interferon-gamma / physiology*
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Mice
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Mice, Inbred C57BL
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Mice, Inbred Strains
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Myelin Sheath / pathology
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Myelin Sheath / virology
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Poliomyelitis / immunology
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Poliomyelitis / pathology
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Species Specificity
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Spinal Cord / pathology*
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Spinal Cord / virology
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Theilovirus / immunology
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Theilovirus / isolation & purification
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Theilovirus / pathogenicity*
Substances
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Antibodies, Monoclonal
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Antibodies, Viral
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Antigens, Viral
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Immunoglobulin G
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Immunoglobulin M
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Interferon-gamma