Abstract
Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) is important for primary B-lymphocyte growth transformation. We now demonstrate that the W repeat-encoded domain of EBNA-LP significantly associates with proteins of the heat shock protein 70 family (hsp72/hsc73). hsp72/hsc73 may mediate the previously observed interaction between EBNA-LP and the retinoblastoma protein or p53.
Publication types
-
Comparative Study
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Antigens, Viral / biosynthesis
-
Antigens, Viral / isolation & purification
-
Antigens, Viral / metabolism*
-
B-Lymphocytes / immunology
-
B-Lymphocytes / physiology
-
B-Lymphocytes / virology
-
Cell Line
-
DNA-Binding Proteins / biosynthesis
-
DNA-Binding Proteins / isolation & purification
-
DNA-Binding Proteins / metabolism*
-
Electrophoresis, Polyacrylamide Gel
-
Epstein-Barr Virus Nuclear Antigens
-
Gene Expression
-
HSC70 Heat-Shock Proteins
-
HSP70 Heat-Shock Proteins*
-
HSP72 Heat-Shock Proteins
-
Heat-Shock Proteins / chemistry
-
Heat-Shock Proteins / isolation & purification
-
Heat-Shock Proteins / metabolism*
-
Humans
-
Lymphocyte Activation
-
Methionine / metabolism
-
Molecular Sequence Data
-
Protein Binding
-
Recombinant Proteins / biosynthesis
-
Recombinant Proteins / isolation & purification
-
Recombinant Proteins / metabolism
-
Retinoblastoma Protein / metabolism
-
Trans-Activators / isolation & purification
-
Trans-Activators / metabolism
-
Tumor Suppressor Protein p53 / metabolism
Substances
-
Antigens, Viral
-
DNA-Binding Proteins
-
Epstein-Barr Virus Nuclear Antigens
-
HSC70 Heat-Shock Proteins
-
HSP70 Heat-Shock Proteins
-
HSP72 Heat-Shock Proteins
-
HSPA8 protein, human
-
Heat-Shock Proteins
-
Recombinant Proteins
-
Retinoblastoma Protein
-
Trans-Activators
-
Tumor Suppressor Protein p53
-
Methionine