Abstract
The influence of 2-CdA administrated alone and in combination with CY or MTX on the survival time of mice bearing L1210 leukemia was investigated. 2-CdA treated mice lived longer than control animals. Survival times of mice receiving combined therapy of 2-CdA and CY were significantly prolonged as compared with mice treated with these agents separately. Survival times of mice treated with 2-CdA and MTX were not significantly prolonged, compared with animals receiving 2-CdA alone.
MeSH terms
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Animals
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Antimetabolites, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / pharmacology*
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Antineoplastic Combined Chemotherapy Protocols / pharmacology*
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Cladribine / administration & dosage
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Cladribine / pharmacology*
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Cyclophosphamide / administration & dosage
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Dose-Response Relationship, Drug
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Drug Synergism
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Female
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Leukemia L1210 / drug therapy*
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Methotrexate / administration & dosage
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Mice
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Mice, Inbred DBA
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Neoplasm Transplantation
Substances
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Antimetabolites, Antineoplastic
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Cladribine
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Cyclophosphamide
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Methotrexate