Abstract
CD19 and CD21 are B-cell surface molecules that associate with each other and with CD81 and Leu-13 to generate a signal transduction complex that is independent of the antigen receptor. Current studies, reviewed here by Thomas Tedder, Liang-Ji Zhou and Pablo Engel, indicate an important biological role for this protein complex in the regulation of B-cell development and activation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, CD / biosynthesis
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Antigens, CD / immunology*
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Antigens, CD19
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Antigens, Differentiation / biosynthesis
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Antigens, Differentiation / immunology
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Antigens, Differentiation, B-Lymphocyte / biosynthesis
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Antigens, Differentiation, B-Lymphocyte / immunology*
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B-Lymphocytes / immunology*
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Humans
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Molecular Sequence Data
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Receptors, Complement 3d / biosynthesis
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Receptors, Complement 3d / immunology*
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Signal Transduction / immunology*
Substances
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Antigens, CD
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Antigens, CD19
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Antigens, Differentiation
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Antigens, Differentiation, B-Lymphocyte
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Receptors, Complement 3d
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leu-13 antigen