Abstract
The effect of human granulocyte colony stimulating factor (hG-CSF) was investigated on the proliferation of choriocarcinoma cells in vitro. No growth-stimulating effect was observed. Then, 22 patients with invasive mole and 9 patients with choriocarcinoma who received combination chemotherapy were treated with hG-CSF when white blood cell counts decreased below 2,000/mm3. The duration of neutropenia was reduced significantly by 3-4 days with the use of hG-CSF. No side effects were observed. These results indicate safety and usefulness of hG-CSF as an adjunct to chemotherapy in the treatment of gestational trophoblastic disease.
MeSH terms
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Adult
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / therapeutic use
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Cell Division / drug effects
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Choriocarcinoma / blood
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Choriocarcinoma / drug therapy*
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Female
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Granulocyte Colony-Stimulating Factor / pharmacology
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Granulocyte Colony-Stimulating Factor / therapeutic use*
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Humans
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Hydatidiform Mole, Invasive / blood
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Hydatidiform Mole, Invasive / drug therapy*
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Male
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Middle Aged
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Neutropenia / chemically induced
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Neutropenia / pathology
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Neutropenia / prevention & control*
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Pregnancy
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Retrospective Studies
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Tumor Cells, Cultured
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Uterine Neoplasms / blood
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Uterine Neoplasms / drug therapy*
Substances
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Antineoplastic Agents
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Granulocyte Colony-Stimulating Factor