Abstract
Purpose:
We assessed the role of surgery, particularly exenteration, in the treatment of children with lower urinary tract and pelvic rhabdomyosarcoma.
Materials and methods:
We treated 23 children with bladder and/or prostate (11), or pelvic retroperitoneal tumors (12). Initial management was tumor resection in 6 cases, anterior pelvic exenteration in 5 and biopsy only in 12, combined with chemotherapy in 23 and radiotherapy in 20.
Results:
The bladder salvage rate for surviving patients with pelvic tumors was 92% versus 27% for those with prostate/bladder tumors. Estimated 5 and 10-year survival probability for patients with pelvic retroperitoneal tumors was 49 +/- 50% compared to 81 +/- 24% for those with bladder and/or prostate tumors (log rank test, p = 0.11).
Conclusions:
Exenterative surgery is frequently required to achieve a durable complete response.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Review
MeSH terms
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Actuarial Analysis
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Adolescent
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Child
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Child, Preschool
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Combined Modality Therapy
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Female
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Humans
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Infant
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Infant, Newborn
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Male
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Neoplasm Recurrence, Local / epidemiology
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Pelvic Neoplasms / mortality
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Pelvic Neoplasms / surgery*
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Pelvic Neoplasms / therapy
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Prostatic Neoplasms / mortality
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Prostatic Neoplasms / surgery*
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Prostatic Neoplasms / therapy
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Retroperitoneal Neoplasms / mortality
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Retroperitoneal Neoplasms / surgery*
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Retroperitoneal Neoplasms / therapy
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Retrospective Studies
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Rhabdomyosarcoma / drug therapy
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Rhabdomyosarcoma / mortality
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Rhabdomyosarcoma / radiotherapy
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Rhabdomyosarcoma / surgery*
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Survival Rate
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Urinary Bladder Neoplasms / mortality
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Urinary Bladder Neoplasms / surgery*
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Urinary Bladder Neoplasms / therapy
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Urinary Diversion