The effect of tenoxicam on tolbutamide pharmacokinetics and glucose concentrations in healthy volunteers

R O Day; G Geisslinger; P Paull; K M Williams

The effect of tenoxicam on tolbutamide pharmacokinetics and glucose concentrations in healthy volunteers

Int J Clin Pharmacol Ther. 1995 May;33(5):308-10.

Authors

R O Day¹, G Geisslinger, P Paull, K M Williams

Affiliation

¹ Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital Sydney, Australia.

PMID: 7655772

Abstract

There was no significant difference in the pharmacokinetic parameters of tolbutamide (500 mg) determined before and after 14 days treatment with tenoxicam (20 mg/day) in 7 healthy volunteers (6 male, 1 female). In addition, co-administration of tenoxicam did not alter blood glucose concentrations.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Analysis of Variance
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Blood Glucose / metabolism*
Chromatography, High Pressure Liquid
Computer Simulation
Drug Interactions
Female
Humans
Male
Middle Aged
Piroxicam / administration & dosage
Piroxicam / analogs & derivatives*
Piroxicam / pharmacology
Tolbutamide / administration & dosage
Tolbutamide / blood
Tolbutamide / pharmacokinetics*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Blood Glucose
Piroxicam
Tolbutamide
tenoxicam