MR findings of a patient with hemolytic uremic syndrome involving the CNS are described. Abnormal high signal intensity on T2-weighted images combined with swelling in the lentiform nucleus, posterior limb of internal capsule, external capsule bilaterally, and left extreme capsule was shown on initial MR; a small low signal intensity in the left putamen on T1- and T2-weighted images and generalized atrophy in the area of high signal intensity on previous T2-weighted images was shown on follow-up MR. These findings indicate infarct with focal hemorrhage, which is one of the histopathological features of CNS complication in hemolytic uremic syndrome.