The effectiveness of interventions on incubation of AIDS as measured by secular increases within a population

Stat Med. 1994 Oct;13(19-20):2127-39. doi: 10.1002/sim.4780131920.

Abstract

Methods are developed to estimate and test for the impact of intervention use on a population's survival function (time to AIDS). Each participant's history is divided into J + 1 components: omega 0 occurring before the intervention is available and omega 1 to omega J occurring later, as the intervention becomes successively more available. Distribution free truncated Kaplan-Meier models based on time since exposure fit separately to the risk sets/outcomes in omega 0 to omega J directly show the changing patterns of survival. Multivariate proportional hazards models can be used to adjust for covariates. Application of these methods indicates that availability of proven anti-AIDS interventions may have delayed time to AIDS by 8 months in an educated HIV-1 infected homosexual cohort with good access to medical care.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / epidemiology
  • Acquired Immunodeficiency Syndrome / mortality
  • Acquired Immunodeficiency Syndrome / therapy*
  • Age of Onset
  • Cohort Studies
  • Disease Progression
  • Disease-Free Survival
  • HIV Infections / epidemiology
  • HIV Infections / mortality
  • HIV Infections / therapy*
  • HIV Seropositivity / epidemiology
  • Homosexuality, Male
  • Humans
  • Male
  • Models, Statistical*
  • Multicenter Studies as Topic
  • Multivariate Analysis
  • Proportional Hazards Models
  • Statistics, Nonparametric
  • Time Factors
  • Treatment Outcome