Abstract
A reaction cassette has been designed for the highly sensitive detection of the making and breaking of chemical bonds. The system is envisioned as a companion device to be used in the search for antibody and other novel catalysts. The cassette also may have important clinical applications in the design of diagnostic reagents. In its fully encoded format, this methodology is capable of both detecting and decoding chemical events.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibodies / metabolism
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Base Sequence
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Catalysis
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Chemistry / methods*
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DNA / chemical synthesis*
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DNA Primers / chemical synthesis*
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Endopeptidases / metabolism*
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Enzyme-Linked Immunosorbent Assay
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Molecular Sequence Data
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Mutagenesis, Insertional*
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Oligodeoxyribonucleotides / chemical synthesis*
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Peptides / chemistry*
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Polymerase Chain Reaction / methods*
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Sensitivity and Specificity
Substances
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Antibodies
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DNA Primers
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Oligodeoxyribonucleotides
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Peptides
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DNA
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Endopeptidases