Immunogenicity study of a synthetic T-cell epitope of rubella virus capsid protein recognized by human T cells in different strains of mice

Viral Immunol. 1994;7(1):41-5. doi: 10.1089/vim.1994.7.41.

Abstract

The immunogenicity of a human immunodominant T-cell epitope C9 (residues 205-233) of rubella virus capsid protein was studied in three strains of mice using C9 lipopeptide. This peptide induced strong T-cell responses in all three strains of mice. The minimal T-cell epitope C9B (residues 205-216) recognized by human T cells with HLA-DR4 phenotype did not specifically stimulate proliferation of T cells from mice in vitro. T cells specific for C9 from immunized mice were shown to be CD4+, in agreement with results of similar studies in RV-seropositive humans.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cells, Cultured
  • Female
  • Humans
  • Immunodominant Epitopes / immunology*
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Molecular Sequence Data
  • Peptide Fragments / immunology*
  • Rubella virus / immunology*
  • Species Specificity
  • Viral Core Proteins / immunology*

Substances

  • Immunodominant Epitopes
  • Peptide Fragments
  • Viral Core Proteins
  • nucleocapsid protein (C), rubella virus