Hypercalcemia, monoclonal protein, and osteolytic bone lesions in chronic lymphocytic leukemia

Ann Hematol. 1994 Aug;69(2):79-80. doi: 10.1007/BF01698486.

Abstract

We describe a patient with a long history of typical chronic lymphocytic leukemia (CLL) who developed hypercalcemia, osteolytic bone lesions, and a monoclonal protein, all features of a secretory plasma cell disorder. These features in CLL have been reported in only four previous cases. The hypercalcemia in our patient is felt to result from an increase in the osteoclastic process.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Humans
  • Hypercalcemia / complications*
  • Immunoglobulin M / metabolism*
  • Immunoglobulin kappa-Chains / metabolism*
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications*
  • Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
  • Male
  • Osteolysis / complications*

Substances

  • Immunoglobulin M
  • Immunoglobulin kappa-Chains