Abstract
To assess the generality of the hypothesis that murine double-minute-2 (MDM-2) gene amplification complements the absence of p53 mutation during tumor development, we analyzed 143 murine tumors induced by a variety of carcinogenic agents in two different mouse strains. Only three of 143 tumors showed p53 genetic alterations and none showed MDM-2 amplification, indicating the existence of alternative pathways that permit tumor cells to bypass p53-MDM-2 control.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Female
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Gene Amplification / genetics*
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Genes, p53 / genetics*
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Harderian Gland / drug effects
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Harderian Gland / physiology
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Hyperplasia
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Lymphoma / chemically induced
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Lymphoma / etiology
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Lymphoma / genetics
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Mammary Neoplasms, Experimental / genetics
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Methylnitrosourea
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Mice
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Mice, Inbred DBA
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Mice, Transgenic
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Molecular Sequence Data
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Neoplasm Proteins / genetics*
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Neoplasms, Experimental / chemically induced
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Neoplasms, Experimental / etiology
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Neoplasms, Experimental / genetics*
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Neoplasms, Radiation-Induced / etiology
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Neoplasms, Radiation-Induced / genetics
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Nuclear Proteins*
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Proto-Oncogene Proteins c-mdm2
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Proto-Oncogene Proteins*
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Thymus Neoplasms / chemically induced
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Thymus Neoplasms / etiology
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Thymus Neoplasms / genetics
Substances
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Neoplasm Proteins
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Nuclear Proteins
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Proto-Oncogene Proteins
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Methylnitrosourea
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Mdm2 protein, mouse
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Proto-Oncogene Proteins c-mdm2