Abstract
The specificity of the tumor cell immunoglobulin in three cases of low grade B cell gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma has been studied. Using anti-idiotypic antibodies to detect the reactivity of tumor immunoglobulin in tissue sections from the patients and other individuals, we observed specificity for normal tissue components in all three cases studied. Reactivity in one case was with follicular dendritic cells, in the second case with a novel antigen on mucosal post capillary venules, and, in the third case, a broad pattern of reactivity was observed. This study suggests that autoimmunity may play a role in the pathogenesis of gastric lymphoma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Anti-Idiotypic / chemistry
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Antibodies, Monoclonal / chemistry
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Antibody Specificity*
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Antigen-Antibody Reactions
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Enzyme-Linked Immunosorbent Assay
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Gastric Mucosa / chemistry
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Gastric Mucosa / immunology*
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Gastric Mucosa / pathology
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Gastrointestinal Neoplasms / chemistry
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Gastrointestinal Neoplasms / immunology*
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Gastrointestinal Neoplasms / pathology
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Humans
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Immunoglobulins / analysis*
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Immunohistochemistry
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Lymphoid Tissue / chemistry
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Lymphoid Tissue / immunology*
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Lymphoid Tissue / pathology
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Lymphoma, B-Cell / immunology*
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Lymphoma, B-Cell / pathology
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Lymphoma, Non-Hodgkin / immunology*
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Lymphoma, Non-Hodgkin / pathology
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Tissue Distribution
Substances
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Antibodies, Anti-Idiotypic
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Antibodies, Monoclonal
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Immunoglobulins