The effects of the angle of incidence of the ultrasound beam on the image quality were studied in 21 pressurized arterial specimens examined with a 30 MHz intravascular ultrasonographic catheter. When the ultrasonographic catheter was in an eccentric position in the vessel lumen, the videodensity of the segments of the vessel wall with the least favorable angle of interrogation (a shift of 49 +/- 6 degrees from the tangent to the tissue surface) was 27% +/- 19% lower than the videodensity measured with the catheter in the center of the lumen. When the catheter was placed in a position that was not parallel to the long axis of the vessel, a further decrease was observed, especially in the vessel wall opposite the position of the catheter. An artificial dissection was induced in eight specimens. Dropouts that involved the dissection plane and the underlying structures were produced with positions of the echographic catheter inducing a narrow angle between ultrasound beam and dissection plane. These experimentally induced artifacts were compared with similar findings from the in vivo evaluation of peripheral and coronary arteries. The angle of incidence of the ultrasound beam is a major determinant of the image quality in intravascular ultrasonography. Angle-dependent artifacts occur with eccentric and noncoaxial positions of the ultrasonographic catheter and, in particular, with imaging of large intraluminal dissections. Awareness of this problem may prevent image misinterpretation and has relevance for future improvement of catheter technology and design.