Abstract
In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Breast Neoplasms / genetics*
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Chromosome Mapping / methods*
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Chromosomes, Human, Pair 17*
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DNA, Neoplasm / analysis
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DNA, Satellite / analysis
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Family Health
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Female
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Genetic Linkage
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Genetic Markers
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Genetic Variation
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Humans
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Lod Score
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Male
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Middle Aged
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Neoplastic Syndromes, Hereditary / genetics
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Ovarian Neoplasms / genetics*
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Pedigree
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Polymorphism, Genetic
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Proto-Oncogenes*
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Recombination, Genetic
Substances
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DNA, Neoplasm
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DNA, Satellite
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Genetic Markers