Abstract
Nisoldipine treatment for five months prevented a rise in blood pressure in Cohen diabetic rats with Goldblatt hypertension, compared to a significant elevation in untreated controls. Blood creatinine and urea also decreased significantly in the treated animals, and renal lesions were less severe. The prevalence of glomerulosclerosis, however, remained unaltered in both the treated and control groups. These findings indicate that increased blood pressure aggravates renal changes, while reducing it eliminates the aggravation.
MeSH terms
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Animals
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Blood Pressure / drug effects
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Blood Urea Nitrogen
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Creatinine / blood
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Diabetes Mellitus, Experimental / complications
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Diabetes Mellitus, Experimental / drug therapy*
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Diabetes Mellitus, Experimental / physiopathology
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Diabetic Nephropathies / etiology*
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Diabetic Nephropathies / pathology
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Diabetic Nephropathies / prevention & control
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Hypertension, Renovascular / complications
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Hypertension, Renovascular / drug therapy*
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Hypertension, Renovascular / physiopathology
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Nisoldipine / therapeutic use*
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Phosphorus / blood
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Rats
Substances
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Phosphorus
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Nisoldipine
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Creatinine