A sublocus of the multicopy microsatellite marker CMS1 maps proximal to spinal muscular atrophy (SMA) as shown by recombinant analysis

G van der Steege; J M Cobben; J Osinga; H Scheffer; G J van Ommen; C H Buys

doi:10.1007/BF00197416

A sublocus of the multicopy microsatellite marker CMS1 maps proximal to spinal muscular atrophy (SMA) as shown by recombinant analysis

Hum Genet. 1995 Nov;96(5):589-91. doi: 10.1007/BF00197416.

Authors

G van der Steege¹, J M Cobben, J Osinga, H Scheffer, G J van Ommen, C H Buys

Affiliation

¹ Department of Medical Genetics, University of Groningen, The Netherlands.

PMID: 8530008
DOI: 10.1007/BF00197416

Abstract

The critical region containing the spinal muscular atrophy (SMA) gene is flanked by the 5q11-q13 markers, D5S435 and D5S557, as determined by linkage analysis. Here we present the results of an analysis of a Dutch SMA family with the multicopy microsatellite marker CMS1. A crossover is revealed in the critical SMA region. We conclude that at least one of the CMS1 subloci maps proximal to the SMA gene. This reduces the minimal SMA region from approximately 1.4 Mb to 600-700 kb.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping*
DNA, Satellite / analysis*
Female
Humans
Male
Muscular Atrophy, Spinal / genetics*
Polymerase Chain Reaction

Substances

DNA, Satellite