Abstract
We analysed the effect of ethanol on basal cytosolic-free calcium concentration ([Ca2+]i) in cultured rat myocytes. Ethanol caused a dose-dependent decrease of the resting [Ca2+]i. Removal of ethanol was followed by a transitory increase of [Ca2+]i above the basal level. In cells chronically exposed to ethanol, [Ca2+]i normalized to the previous level.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcoholism / physiopathology
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Animals
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Calcium / metabolism*
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Cell Survival / drug effects
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Cell Survival / physiology
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Culture Techniques
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Cytosol / drug effects*
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Cytosol / physiology
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Dose-Response Relationship, Drug
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Drug Tolerance
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Ethanol / toxicity*
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Male
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Muscle, Skeletal / drug effects*
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Muscle, Skeletal / physiopathology
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Rats
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Rats, Wistar