Trisomy 13 in a case of myelofibrosis with myeloid metaplasia with early blastic transformation

F Ferrara; L Vicari; B Festa; R Di Noto; F Pane; L Sebastio; R Cimino

Trisomy 13 in a case of myelofibrosis with myeloid metaplasia with early blastic transformation

Haematologica. 1995 Sep-Oct;80(5):434-6.

Authors

F Ferrara¹, L Vicari, B Festa, R Di Noto, F Pane, L Sebastio, R Cimino

Affiliation

¹ Divisione di Ematologia, Ospedale Cardarelli, Naples, Italy.

PMID: 8566885

Abstract

We describe a case of early myeloid blastic transformation in a 64-year-old man suffering from myelofibrosis with myeloid metaplasia. Both chronic and blastic phase cytogenetic analysis showed trisomy 13 to be the sole chromosome aberration. A potential role for this rare abnormality in determining such an unusually poor clinical outcome is discussed.

Publication types

Case Reports

MeSH terms

Blast Crisis / pathology
Chromosomes, Human, Pair 13*
Fatal Outcome
Humans
Karyotyping
Male
Middle Aged
Primary Myelofibrosis / genetics*
Primary Myelofibrosis / pathology
Proto-Oncogene Proteins / genetics
Receptor Protein-Tyrosine Kinases / genetics
Trisomy*
fms-Like Tyrosine Kinase 3

Substances

Proto-Oncogene Proteins
FLT3 protein, human
Receptor Protein-Tyrosine Kinases
fms-Like Tyrosine Kinase 3