Abstract
Clonal chromosome and/or hematological abnormalities typically observed in myelodysplastic syndromes (MDS) have been described with increased frequency after autologous bone marrow transplantation (BMT) for lymphoma. We report the case of a woman with chronic myelogenous leukemia (CML) allografted with her HLA-identical sibling who, 5 years after the transplant and under immunosuppressive treatment for chronic graft host disease (GVHD), suffered a cytogenetic relapse associated with a 5q- deletion in the host metaphases. These findings suggest that myelodysplastic changes, possibly related to the chemo-radiotherapy conditioning regimen, may also present after allogeneic BMT.
MeSH terms
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Adult
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Azathioprine / adverse effects*
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Azathioprine / therapeutic use
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Bone Marrow Transplantation*
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Chromosome Deletion*
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Chromosomes, Human / drug effects
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Chromosomes, Human / radiation effects
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Chromosomes, Human, Pair 5 / ultrastructure*
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Combined Modality Therapy
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Cyclophosphamide / adverse effects*
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Cyclosporine / therapeutic use
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Eosinophilia / drug therapy
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Fasciitis / drug therapy
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Female
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Graft vs Host Disease / prevention & control
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Humans
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Hydroxyurea / adverse effects*
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Hydroxyurea / therapeutic use
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Immunosuppressive Agents / therapeutic use
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
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Methotrexate / therapeutic use
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Recurrence
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Whole-Body Irradiation / adverse effects*
Substances
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Immunosuppressive Agents
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Cyclosporine
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Cyclophosphamide
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Azathioprine
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Hydroxyurea
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Methotrexate